Generic Zithromax is aт antibiotic...
Generic Zithromax is aт antibiotic used for the treatment of bacterial infections caused by susceptible to azithromycin microorganisms. This medication is a generic form meaning that it contains the same active ingredient as brand drug namely Azithromycin.
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Generic Zithromax is a prescription antibiotic used for the treatment of bacterial infections caused by susceptible to azithromycin microorganisms. This medication is a generic form meaning that it contains the same active ingredient as brand drug namely Azithromycin. Generic Zithromax may differ from brand in shape, color of the tablets and amount of excipients. Therapeutic activity is similar. Generic medication is made by well known drug manufacturer Cipla.
Azithromycin is a macrolide antibiotic which possesses a broad spectrum of antibacterial activity. The medication is active against a wide range of microorganisms including gram-negative and gram-positive bacteria. The medication exerts bacteriostatic action through the inhibiting the synthesis of protein in bacterial cell. Azithromycin binds to 50S subunits of the ribosomes and inhibits the enzyme called peptidyl translocase at the stage of translation and interferes with the biosynthesis of protein. Azithromycin slows the growth and replication of bacteria.
The broad spectrum of antibacterial activity includes:
Gram-positive microorganisms: Streptococcus group C, F, G, including producing beta-lactamase, Streptococcus viridians, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus epidermidis, Staphylococcus aureus, Streptococcus spp.
Gram negative microorganisms: Gardnerella vaginalis, Neisseria gonorrhoeae, Haemophilus influenzae, Moraxella catarrhalis, Campylobacter jejuni, Haemophilus ducrei, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila.
Anaerobic microorganisms: Peptostreptococcus spp, Bacteroides bivius, Clostridium perfringens Peptococcus.
Intracellular microorganisms: Chlamydia (Chlamydia trachomatis, Chlamydia pneumoniae), ureoplasma (Ureaplasma urealyticum), spirochete (Treponema pallidum, Borrelia burgdorferi), bacteroids, mycoplasma (Mycoplasma pneumoniae), mycobacteria (Mycobacteria avium complex).
Azithromycin is active against Helicobacter pylori. Generic Zithromax is not active against gram-positive bacteria which are resistant to erythromycin.
Generic Zithromax possesses a therapeutic effects more frequently than beta-lactam antibiotics in cases when it is impossible to identify the infectious agent. Due to its good tolerability and high effectiveness azithromcycin is a drug of choice in the treatment of sexually transmitted diseases, urogenital infections, mixed infections.
Clinical studies have shown that the clinical efficacy of azithromycin is achieved at a single daily dose 500mg 3 times daily and is comparable to the effectiveness of other antibacterial drugs. This in its turn allows significantly reduce the duration of antibacterial therapy.
Generic Zithromax possesses the following pharmacokinetic characteristics:
After oral administration, azithromycin is well absorbed into the blood circulation and rapidly distributed in the body. It is stable in acid medium, lipophilic. After a single dose of 500 mg the bioavailability is 37% (effect of "first passage"), Cmax (0,4 mg /l) is achieved after 2-3 hours, the volume of distribution - 31,1 l/kg and protein binding is inversely proportional to the concentration in the blood and is 7-50%. Food intake can significantly change the pharmacokinetics (depending on dosage form). Due to its long high-life period the medication is slowly eliminates out of the organisms and therapeutic concentrations of the medication remains high for a period of 5-7 days after the last application. Generic Zithromax is easily penetrates through the blood barriers and inters the tissues. The concentration of the medication in lungs, respiratory system, urogenital system, skin and soft tissue is higher than its concentration in blood plasma. Azithromycin penetrates through the cell membranes (is effective for infections caused by intracellular pathogens). Then it is transported along with phagocytes, polymorphonuclear leukocytes and macrophages to the site of infection, where is released in the presence of bacteria. The concentration of Azithromycin at the place of infection is 23-24% higher than in healthy tissues. Generic Zithromax is metabolized in the liver and eliminates with bile and urine generally in unchanged form.
Generic Zithromax (Azithromycin) is licensed to treat infectious diseases caused by susceptive (sensitive) to the medication bacteria:
Infections of the upper respiratory tract and ENT (ear, nose and throat infections) such as bacterial pharyngitis / tonsillitis, sore throat, laryngitis, sinusitis, otitis media);
The medication is not indicated for the treatment of viral infections such as common cold, flu .
You should take the medications exactly as prescribed by your physician. You should finish the entire course of treatment even if you start feeling much better. This will help to avoid the development of secondary infections. Tablets should be taken with a glass of water swallowing as a whole. Tablets should not be crashed or chewed. It is preferably to take Azithromycin tablets at the same time every day. In certain cases your health care provider may decide to make some tests to determine if the bacteria are sensitive to Azithromycin. For the treatment of mild and moderate infections your physician may prescribe this medicine without prior examinations.
Azithromycin tablets should be taken one hour before meal and 2 hours after meals.
The indicated dose of generic Zithromax depends on the following conditions:
The recommended dose for patients with liver or kidney diseases should be reduced.
Generic Zithromax is contraindicated for patients with severe liver and kidney dysfunction, known reactions of hypersensitivity to any of the drug ingredients, allergic reactions to macrolide antibiotics.
Generic Zithromax is contraindicated in pregnant women and breastfeeding mothers. Azithromycin is a pregnancy category B meaning that is was not studied in pregnant women. When the medication was studied in laboratory animals it didn't cause any damage to the fetus.
Generic Zithromax side effects
Azithromycin represents one of the safest macrolide antibiotic. Numerous clinical studies have shown good tolerability of azithromycin in patients of all age groups. In most cases Generic Zithromax side effects are mild or moderate and do not require the cessation of therapy. The medication may cause the following side effects:
How the medication can interact with other medicines?
You should store the medication at dry and protected from light place out of reach of children. Do not keep the medicine in a bathroom.