Cefixime is effective and safe oral...
Cefixime is effective and safe oral antibiotic which belongs to a group of medicines called 3rd generation cephalosporins. Cefixime is characterized by a broad spectrum of antibacterial action, high effectiveness and safety profile.
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Cefixime is effective and safe oral antibiotic which belongs to a group of medicines called 3rd generation cephalosporins. Cefixime is characterized by a broad spectrum of antibacterial action, high effectiveness and safety profile. Cefixime is used to treat respiratory and ENT infections, infections of the Urogenital system, infections of the skin and bones, uncomplicated gonorrhea, gram (-) infections in children.
Cefixime is semi-synthetic cephalosporin antibiotic for oral administration which belongs to the III generation cephalosporins. Cefixime exerts bactericidal action against a wide variety of microorganisms.
Action mechanism consists in inhibition of peptidoglycan synthesis - the main structural component of bacterial cell wall. Cefixime is resistant to the action of beta-lactamases.
Cefixime is characterized by a broad spectrum of antibacterial activity, high efficiency and safety for use in children over 6 years of age.
Cefixime is active against many gram-positive and gram-negative microorganisms: Providencia species, Serratia marcescens, Proteus mirabilis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Haemophilus influenzae, Haemopbilus paramfluenzae, Moraxella catarrhalis (Branhamella), Esherichia coli, P.vulgaris, Proteus mimbilis, N. gonorrhoeae, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, , Salmonella spp, Shigella spp., Citrobacter diversus. The medication is not used for the treatment of Staphylococcus aureus infection.
Cefixime was synthesized in 1987 by Fujisava Pharmacevtical Co. Ltd, Osaka, Japan. At the present time it is successfully used in over 80 countries worldwide.
After oral administration the bioavailability is 45 - 50%. Maximal blood concentration is achieved after 4 hours. The maximal concentration is achieved faster when the medication is taken with food. More than 65% of the medication binds to albumin. Nearly 50% of the dose is excreted with the urine in unchanged form within 24 hours; nearly 10% of the dose is excreted with bile.
The half-life period is dose-dependent and varies from 3 to 4 hours.
In children with impaired renal function (creatinine clearance 20-40 ml / min) half-life increases up to 6.4 hours, in creatinine clearance 5 - 10 ml/min - up to 11, 5 hours.
Cefixime tablets are indicated for the treatment of infectious diseases caused by sensitive (susceptible to) the medication microorganisms (bacteria):
Cefixime oral should be taken exactly as prescribed by your health care provider. Do not use generic Suprax without consultation with your physician. Cefixime tablets are taken orally with sufficient amount of water swallowing whole. Do not crash, chew or split the tablets. You should not stop taking the medicine if you start feeling better (you should finish the prescribed course of treatment till the end). The dose for patients with creatinine clearance less than 20ml/min should be reduced.
The medication is contraindicated in the following conditions:
Cefixime should be used with caution in patients with:
In appropriate use generic Suprax does not cause any significant side effects. During clinical trials there were reported the following Cefixime side effects:
Digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, bloating, transient increases in liver transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, gastrointestinal candidiasis, dybacteriosis; in rare cases - stomatitis, glossitis, pseudomembranous enterocolitis. Hemopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia. CNS: dizziness, headache. Urinary tract: interstitial nephritis.
Allergic reactions: skin itching, rash, skin hyperemia, eosinophilia, fever
Other: vaginitis, genital pruritus, and candidiasis has been reported.
In case of overdose generic Suprax may cause stomach disturbances, cns disorders, changes in blood cell counts. In cases of Suprax overdose symptomatic treatment is required:
In certain cases a health care provide may give antihistamines or corticosteroids
The blockers of calcium secretion (allopurinol, diuretics) may decrease the excretion of cefixim by kidneys. This may increase Suprax toxicity.
Cefixime should be stored at dry and protected from light place at room temperature out of reach of children. Do not store the medicine in a bathroom.