Tretionin is a natural metabolite of...
Tretionin is a natural metabolite of retinol that works by suppressing gene expression, which initiates a modification synthesis of proteins. Retin-A cream penetrates the cells (their membranes) and forms complexes with specific cytoplasmic
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Retin A is a natural acne medication that contains tretionin.
Tretionin is a natural metabolite of retinol that works by suppressing gene expression, which initiates a modification synthesis of proteins. Retin-A cream penetrates the cells (their membranes) and forms complexes with specific cytoplasmic receptors that penetrate the cell nucleus and connect with DNA (genetic material). Depending on tissue condition, tretionin inhibits protein synthesis, or activates the process of transcription and increases the number of m-RNA.
Retin-A inhibits the gene transcription factor (AP-I), which makes it possible to achieve cessation or reduction of protein synthesis and smoothes the adverse effects of the sun's rays on the skin (including hyperpigmentation).
Retin-A reduces the amount of melanin in the epidermis.
Retin-A cannot protect from sunlight and should not be used as a remedy for sunburn. Transcription amplification leads to an increase in the number of epithelial cells, which are in mitosis condition that causes the induction of proliferation processes in the papillary dermal layer and allows the epithelium to renovate.
Retin-A reduces the adhesion of those cells that participate in the formation of acne vulgaris, prevents the formation of traffic jams (keratin), and increases the synthesis of substances that are similar to glycosaminoglycans in the corneal epithelium. When applied to open wrinkles Retin-A smoothes skin surface without inflammatory attributes.
When Retin A is applied on the closed wrinkles it helps them to become papules or open acne forms. It also prevents the occurrence of new acne. There is evidence that Retin-A inhibits the synthesis of keratin, has antitumor effects and promotes hair growth.
Retin A is actively used in the treatment of acne vulgaris, follicular keratosis, verruca plana (flat wart), hyperpigmentation. Retin-A cream is actively used in wrinkles and facial tuberosity related to the influence of sunlight (as additional therapy)
Mode of administration
Retin A cream is intended for topical use. The drug is applied to the site of the lesion with a thin layer once daily at bedtime and leave on the skin surface for six hours (for dry skin - only 30 minutes). After that you need to wash your face with tap water. If necessary, you can use cream twice daily. The duration of treatment depends on the type of pathology: therapeutic efficacy in the treatment of acne vulgaris is observed in 14-21 days; in most cases it is required in 42-49 days. Optimal clinical results are observed in 90-day therapy. When Retin A is used to remove the adverse effects from the influence of sunlight positive effect is achieved in the period from 4 to 24 weeks. For prophylaxis Retin-A is used once in seven days after having a bath with warm water. The treatment of flat warts begins with small concentrations. In insufficient effect the dose can be gradually increased.
Do not apply the medication if you have any allergic reactions of reactions of hypersensitivity to any of the medication ingredients. Retin A is should not be used in:
Avoid getting the medication on the mucous membranes in the mouth and eyes. Avoid direct sunlight during the treatment. In 7 days after initiation of treatment there is a risk for more pimple occurrence due to the fact Retin-A acts on deep wrinkles that were not visible before the beginning of therapy.
You should not use Retin-A together with drugs that cause desquamation of the epithelium. Try to avoid using the medication in conjunction with hygienic and cosmetic products which trigger irritation and skin dryness.
In rare cases, you can use a combination of Retin-A and isotretinoin (oral) for the treatment of acne vulgaris. If negative effects occur, the dosage of oral preparation should be reduced. Retin-A is used to treat acne of mild to moderate severity. In severe cases it can be combined with benzoyl peroxide or with systemic and local antibiotics. There is no data about the safety and efficacy of the drug in the treatment of skin tumors and dermatoses. It is not recommended to use cream with elastosis of the skin, sluggish skin, skin discoloration and wrinkles.
The most common Retin A side effects include:
Local reactions: swelling, blisters, dryness and exfoliation of the skin, hypopigmentation, photosensibilisation, allergic reactions - edema, itching, hyperemia, stinging at the site of application
Retin-A should not be combined with substances that have abrasive effect or contain lemon, products for hair care and soaps which cause skin dryness; cosmetic preparations that have ethanol or sulfur, aftershave preparations, astringent products, salicylic acid, resorcinol, benzoyl peroxide, local antibiotics (erythromycin, clindamycin). All these products when are used with Retin-A lead to increase of skin dryness and irritation.
Retin-A improves the absorption of minoxidil and its speed leadinh to increased intensity of hair growth and increases the likelihood of skin irritation.
Retin-A can interact with products that increase photosensitivity (including thiazide diuretics, sulfonamides, phenothiazines, fluoroquinolones). When Retin-A is used with other retinoids (oral tretinoin, isotretinoin, etretinate) the risk of skin irritability and dryness is increased