Omeprazole is a prescription...
Omeprazole is a prescription medication that belongs to a group of "stomach" medications called proton pump inhibitors; it is a potent antisecretory and antiulcer remedy.
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Active ingredient: Omeprazole
Omeprazole is a prescription medication that belongs to a group of "stomach" medications called proton pump inhibitors; it is a potent antisecretory and antiulcer remedy. Omeprazole comes in the form of capsules 20mg and 10mg and it is used to treat gastric and duodenal ulcers, reflux esophagitis, NSAID - gasrtoenteropathy, conditions associated by hypesecretion of stomach acid. Omeprazole 20mg is used in combination with antibiotics (amoxicillin, clarithromycin) to treat Helicobacter pylori infections. It is made by many pharmaceutical companies like GSK, Cipla, Ranbaxy and other. It is available as brand (Prilosec) and generic medication.
Omeprazole is an antiulcer agent, inhibitor of proton pump inhibitor - the enzyme called - H +-K +-ATPase. Antisecretory action mechanism of omeprazole is associated with inhibition of H +-K +-ATPase in gastric parietal cells. This results in blockage of the final stage of hydrochloric acid formation. Omeprazole is converted into an active form in the intracellular tubules of parietal cells, where it inhibits H +-K +-ATPase, located in the apical membrane of secretory cells. Omeprazole 20mg reduces basal and stimulated secretion of hydrochloric acid regardless of the nature of the stimuli.
Omeprazole possesses high lipophilicity, easily penetrates the parietal cells. Therapeutic effect of omeprazole occurs quickly and is dose-dependent. Antisecretory effect after oral administration of 20mg omeprazole occurs within the first hour, maximum in 2 hours. In high level of PH in the stomach, the neutralization of ammonium (produced by Helicobacter Pylori) is not possible. As a result accumulation of ammonium becomes toxic for the microorganism.
Omeprazole is rapidly absorbed from the gastrointestinal tract. Maximum concentration is achieved after 0.5-1 hour. Bioavailability is 30-40%. Plasma protein binding is 90-95%. Omeprazole 20mg is almost completely metabolized in the liver and it excreted with urine by kidney in the form of metabolites.
Omeprazole is indicated for the treatment of the following conditions:
Omeprazole 20mg comes in the form of capsules taken orally. Omeprazole is recommended to take once daily in the morning, swallowing omeprazole capsules 10mg or 20mg whole, without chewing, crushing an empty stomach or just before eating (it is possible dietary).
In cases where the daily dose exceeds 80 mg omeprazole, the dose should be divided into two parts and taken twice daily (every 12 h). The daily dose exceeding 120 mg should be split into 3 doses.
Omeprazole provides rapid elimination of symptoms, within the first two weeks of admission.
Omeprazole capsules 20mg are contraindicated in:
The application of Omeprazole during pregnancy is possible only in case when presumptive benefit for mother overweighs potential risk for fetus. Omeprazole belongs to a pregnancy category C. This means that the medication may cause damage to the fetus. Make sure to inform your doctor if you are planning to become pregnant.
Omeprazole 20mg can pass through breast milk. Therefore the application of Omeprazole capsules during breastfeeding should be avoided.
The following Omeprazole side effects can occur during the treatment:
Omeprazole slows down the metabolism drugs metabolized livers cytochrome P450, and may increase the plasma concentrations of diazepam, carbamazepine, phenytoin, warfarin.
When Omeprazole is indicated with warfarin it is recommended to monitor the concentration of anticoagulant in the blood serum. Omeprazole enhances the effects of coumarins and difenine. Omeprazole decreases the absorption of certain medications which absorption depends on stomach acidity: antibiotics, ketoconazole.
Omeprazole can interact with antacids, disulferam, escitalopram, hiv medications, iron containing supplements and drugs, tacrolumus, voriconazole, clopidogrel and others.
Omeprazole 20mg capsules stored be stored at dry place out of reach of children. Shelf-life is 2 years. Do not take the medication after expiration date indicated on the pack.