Sodium hyaluronate is obtained from...
Sodium hyaluronate is obtained from the bacterial cells and it is dissolved in a sterile saline solution. Sodium hyaluronate is a linear polysaccharide which is naturally present in the synovial fluid and protects and lubricates your joints during movement
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Monovisc prescribing information
Sodium hyaluronate is obtained from the bacterial cells and it is dissolved in a sterile saline solution. Sodium hyaluronate is a linear polysaccharide which is naturally present in the synovial fluid and protects and lubricates your joints during movement. Monovisc is indicated for patients with osteoarthritis to treat their knee pain and inflammation. Monovisc is used in osteoarthritis patients who have already tried non-pharmacological therapies such as diet and exercise and pharmacologic therapies such as pain medications but didn’t show any improvement.
Mechanism of action:
Your knee is protected from the injuries and shocks due to the presence of synovial fluid in the knee joints. Synovial fluid acts as a lubricant and cushion with viscous and rheological properties due to the presence of sodium hyaluronate. With the loss of synovial fluid, the protection is lost and it leads to osteoarthritis and knee pain. Monovisc functions similar to the synovial fluid due to the presence of slightly cross-linked sodium hyaluronate as an active ingredient and thereby it gives relief from the knee pain for up to six months.
How to use Monovisc:
Monovisc is a sterile, viscosupplement and a single injection that is injected into your knee joints by your doctor. You should never try it by yourself. The procedure is called as viscosupplementation because you are supplementing the viscous and rheological properties of Monovisc to protect and lubricate your knees. Skin disinfectants which contain quaternary ammonium salts such as benzalkonium chloride should not be used to prepare the injection site as ammonium salts can precipitate sodium hyaluronate. Any extra fluid present in the joint is removed and then Monovisc is injected only into the knee joint but not into any vein or artery or tissue. It is a single injection and the procedure completes in one-sitting and it provides relief from the knee pain for up to 4-6 months. Usually other viscosupplement products contain low amounts of sodium hyaluronate and that’s why they are given as a series of 3-5 injections. But the concentration of sodium hyaluronate is higher in Monovisc and that’s why a single injection is sufficient and as it is cross-linked, its durability is also more. Pain relief after an injection differs from person to person. The dose of Monovisc varies from patient to patient based on their medical condition and based on their response to the treatment. Your doctor may suggest a repeat treatment if necessary based on your condition.
Monovisc side effects:
Common side effects are redness, rashes, bruises, pain, itching, swelling and effusion in and around the injected joint and tiredness. If the side effects worsen or if they bother you a lot, you should immediately inform your doctor. If serious side effects such as difficulty in breathing, severe back pain, fever, swelling of the lips and tongue and face and throat, increase in the heart beat, sweating, shaking and dizziness occur, then you should consult your doctor immediately to seek medical advice.
The syringe is for single use and as soon as it is opened, Monovisc should be used immediately.
Monovisc is not recommended if you have any joint infections in the knee or skin infections at the injection site or blood circulation problems in your legs.
It is not advisable to use Monovisc in pregnant or breast feeding women or in children.
Monovisc should not be used if you are allergic to any other products containing sodium hyaluronate.
After an injection, you should avoid activities such as standing for a long time, jogging, weight lifting and tennis for at least two days. Avoid all weight bearing activities that apply pressure on your joints.
If you are using any other type of medicines along with Monovisc, it is always safe to discuss with your doctor.