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Guttalax

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Guttalax Drops is a medicine used for laxative purpose in people suffering from constipation.

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GUTTALAX

Guttalax Dosage form, composition and packaging

Drops for internal use in the form of a clear, slightly viscous solution, from colorless to slightly yellowish or slightly yellowish brown.

 

100 ml

sodium picosulphate monohydrate

750 mg

Guttalax Pharmacological action

Laxative. The active ingredient - sodium picosulphate - is a laxative of the triarylmethane group.

As a locally acting laxative, sodium picosulphate after bacterial cleavage in the colon has a stimulating effect on the mucosa of the colon, increasing motility, and promotes accumulation of water and electrolytes in the colon. This leads to the stimulation of defecation, reduction of evacuation time and stool softening.

Guttalax Drug interactions

In case of simultaneous use of Guttalax in high doses and diuretics or GC the risk of electrolyte imbalance (hypokalemia) is increased.

Simultaneous administration of antibiotics may reduce the laxative effect of Guttalax.

Electrolyte imbalance may increase sensitivity to cardiac glycosides.

Guttalax Overdose

Symptoms: in case of high doses administration there may be diarrhea, dehydration, decreased blood pressure, disruption of water and electrolyte balance, hypokalemia, cramps. In addition, there were reports of ischemia of the colon associated with administering Guttalax in doses greatly exceeding recommended ones for routine treatment of constipation.

Guttalax, like other laxatives, in case of a chronic overdose may cause chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism, urolithiasis. Due to the chronic laxative abuse renal tubular damage, metabolic alkalosis and muscle weakness associated with hypokalemia may develop.

Guttalax Indications

As a laxative in the following cases:

  • constipation due to atony and hypotonia of the colon (including in the elderly, in bedridden patients, after surgery, after childbirth and during lactation);
  • constipation caused by the administration of drugs;
  • to regulate the stool in case of hemorrhoids, proctitis, anal fissures (for softer stool consistency);
  • gallbladder diseases, constipation-predominant irritable bowel syndrome;
  • constipation caused by intestinal dysbacteriosis, diet issues.

Guttalax Contraindications

  • ileus;
  • obstructive diseases of the intestines;
  • acute inflammatory bowel disease;
  • acute abdominal diseases, including appendicitis;
  • severe abdominal pain, accompanied by nausea and vomiting, which may be a symptom of the aforementioned severe conditions;
  • severe dehydration;
  • hypersensitivity to sodium picosulphate and other drug components.

Patients with rare hereditary fructose intolerance should not take the drug.

With caution

During the II and III trimester of pregnancy (the same is true about other laxatives) the drug can only be prescribed by a doctor. Active metabolite and its glucuronides are not excreted in breast milk. Thus, the drug can be used during breastfeeding.

Treatment: to reduce the absorption of the drug after ingestion one can induce vomiting or perform gastric lavage. Fluid replacement and correction of electrolyte balance may be required, as well as prescription of antispasmodics.

Guttalax Cautions

It is not recommended to take the drug every day without consulting a doctor for more than 10 days. Long term administration of the drug in high doses can lead to dehydration, electrolyte imbalance, hypokalemia.

Guttalax interactions

In case of simultaneous use of Guttalax in high doses and diuretics or GC the risk of electrolyte imbalance (hypokalemia) is increased.

Simultaneous administration of antibiotics may reduce the laxative effect of Guttalax.

Electrolyte imbalance may increase sensitivity to cardiac glycosides.

Guttalax Pregnancy and lactation

Data on reliable and well-controlled studies in pregnant women are not available. Long experience in the application did not reveal any adverse effects of the drug on pregnancy. Taking the drug in the I trimester of pregnancy is contraindicated.

Studies on the effect of the drug on fertility have not been conducted. Preclinical studies did not reveal any teratogenic effects on reproduction.

Guttalax Side effects

Digestive system: discomfort; nausea, vomiting, cramps and abdominal pain, diarrhea.

Nervous system: dizziness and fainting. Dizziness and fainting, occurring after administration of the drug, may be associated with a vasovagal reaction (e.g., tension during defecation, cramps in the abdomen).

Hypersensitivity reactions of the immune system are possible, including angioneurotic edema and skin reactions.

Guttalax Storage time and conditions

The drug should be stored out of children’s reach in a place protected from light at a temperature not exceeding 30°C. Do not freeze. Shelf life - 3 years.

Guttalax Application in children

It is contraindicated for children under 4 years of age.

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