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Sildenafil SOFT

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Sildenafil soft tab 100 is an erectile dysfunction medication approved to treat male sexual problems namely - erectile dysfunction. The medication works by blocking the enzyme PDE5 that causes blood to outflow from the penis.

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Sildenafil is an erectile dysfunction medication approved to treat male sexual problems namely - erectile dysfunction. The medication works by blocking the enzyme PDE5 that causes blood to outflow from the penis. According to the clinical data Sildenafil containing in Sildenafil helps more than 88% of men suffered from erectile dysfunction to get and maintain satisfactory erection. For most men, medication begins working in 20-30 minutes after taking the medication. 

This medication comes in the form of soft tablets that can be chewed in the oral cavity. This pharmaceutical form of generic Sildenafil is especially convenient for men that have troubles with swallowing coated tablets. Generic Sildenafil soft tabs are made by the pharmaceutical companies Aurochem or Vipro life science under the names Sildisoft or Viprogra soft

Therapeutic action

Sildenafil soft is an oral medicine used to treat erectile dysfunction in men over 18 years old. The medication restores impaiered erectile function and provides natural response to sexual stimulation. It means that Sildenafil soft tab works only in presense of sexual desire. Physiological mechanism of penile erection involves release of nitric oxide (N0) in the cavernous body during sexual stimulation. Nitric oxide activates the enzyme guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP). 

Cyclic GMP interacts with specific proteins of the smooth mucles and causes them to relax. Cyclic GMP is inactivated under the action of PDE-5 (phosphodiesterase type 5). Sildenafil soft is a powerfull inhibitor of PDE5 causing increase of cyclic GMP levels and thus increases blood inflow to penis and prevent its outflow causing strong and lasting erection. 


Sildisoft (Viprogra) is used to treat erectile dysfunction in males over 18 years of age. The medication is made in the form of soft tablets containing 100mg of Sildenafil citrate. How are 

Sildenafil soft tablets taken?  Sildenafil soft tablets are chewable tablets that can be chewed under the tongue. This helps sildenafil to be absorbed into the blood circulation bypassing liver. The recommended dosage of Sildenafil soft is 50mg once daily before sexual intercourse. Soft tablets of Sildenafil usually begin working in 20 minutes. 


Generic Sildenafil soft is contraindicated for use in the following conditions: 

  • Men under 18 years of age 
  • Cardiovascular diseases including congestive heart failure, stroke, arrhythmia, low blood pressure, high blood pressure, history of heart attacks, angina (stenocardia), coronary heart diseases 
  • Vision diseases – retinitis pigmentosa – rare eye problems • Liver dysfunction • Kidneys dysfunction 
  • Blood diseases such as sickle cell anemia, multiple myeloma, leukemia • Priapism or a history of priapism 
  • Conditions characterized by anatomical deformation of the penis: angulation, Peyronie's disease, or cavernosal fibrosis
  • Concomitant application with nitrates and alcohol  Sildenafil soft (sildenafil) is not intended to be used by women as the effectiveness and safety profile was not studied. 

Side effects

The same as brand Sildenafil, generic Sildenafil soft may cause the following side effects: 

  •  Headache, flushing, dizziness 
  •  Dyspepsia 
  •  Nasal congestion 
  •  Vision (mild and transient, mostly to change the color of objects, as well as increased perception of light and a violation of vision sharpness). 

Other less common Sildenafil soft tabs side effects include: high risk of urinary tract infection, diarrhea, respiratory tract infections, back pain, joint pain, Flu-like symptoms. In very rare cases generic Sildenafil soft may cause: dry mouth, vomiting, congestive heart failure, anxiety, insomnia, asthma, cataracts, gout, fainting, temporary vision loss, sudden decrease in or loss of hearing. 

Drug interaction

Inhibitors 3A4 isoforms 2C9 and P450 may reduce the clearance of sildenafil citrate. Sildenafil is a weak inhibitor of cytochrome P450 isoenzymes - 1A2, 2S9, 2S19, 206, 2E1 and ZA4. Reduced clearance of sildenafil is observed in concomitant application with ketoconazole, erythromycin, cimetidine. Tolbutamide, warfarin, selective serotonin reuptake inhibitors, tricyclic antidepressants, thiazides and other diuretics including loop and potassium-sparing diuretics, ACE inhibitors, calcium antagonists, beta-blockers, rifampicin, barbiturates had no effect on the pharmacokinetics of sildenafil. Single administration of antacids (magnesium and aluminum hydroxide) did not affect the bioavailability of sildenafil. Sildenafil can increase the hypotensive effect of alcohol. Sildenafil soft increases the hypotensive effect of nitrates. 

Their concomitant application may lead to severe drop of blood pressure. Sildenafil soft should not be used in combination with alpha blockers, certain antibiotics and fungals, protease inhibitor. Sildenafil soft is not approved to be taken in combination with other erectile dysfunction medicines like Tadalafil Soft, Vardenafil.

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