Lansoprazole is a generic name of...
Lansoprazole is a generic name of well-known medication (Prevacid). Lansoprazole is an antiulcer agent that belongs to a group specific inhibitors of proton pump (H + / K + ATPase).
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Lansoprazole is a generic name of well-known medication (Prevacid). Lansoprazole is an antiulcer agent that belongs to a group specific inhibitors of proton pump (H + / K + ATPase). Lansoprazole otc is metabolized in the gastric parietal cells into active sulfonamide derivative, which inactivates sulfhydryl groups of H + / K + ATPase. By acting on proton pump Lansoprazole blocks the final stage of hydrochloric acid production, reducing both basal and stimulated secretion, regardless of the nature of the stimulus. Lansoprazole does not affect the motility of the gastrointestinal (GI) tract. As the medication is characterized by high safety profile, it is marketed as over-the-counter product. Lansoprazole is manufactured by well-known company Cipla under the commercial name Lanzol.
Which is Lansoprazole pharmacokinetics?
Lansoprazole is rapidly absorbed into the blood circulation after oral administration and reaches its maximum in - 1.7 hours. Lansoprazole otc binds to plasma proteins by 97%. It is metabolized in the liver. The half-life period is 1.3-1.7 hours. Lansoprazole is excreted by kidneys with urine in the form of two main metabolites.
Lansoprazole comes in the form of capsules 30mg and 15mg. Lansoprazole capsules should be taken whole swallowing whole without chewing, splitting or crushing. If a patient experiences problems with swallowing of lansoprazole capsules then it may be opened in to a small amount of orange or tomato juice. The indicated dose of Lansoprazole varies from 15mg to 30mg daily and depends on current medical condition, concomitant diseases, and patient's age.
Lansoprazole is contraindicated for use in:
Children and adolescents under 18 years of age Lansoprazole otc should be used with caution in elderly age, benign and malignant tumors of the gastrointestinal tract, fructose intolerance, syndrome of glucose or galactose malabsorption.
Make sure to inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Before taking Lansoprazole it is necessary to undergo all necessary procedures and examinations to exclude the risk of stomach cancer.
Lansoprazole may cause the following side effects:
Lansoprazole reduces gastric acidity. This can affect the absorption of certain drugs. For example, decreases the bioavailability of ketoconazole, ampicillin esters, and iron salts. Bioavailability of digoxin is increased by 10%, which is clinically insignificant for most patients.
Lansoprazole slows down the elimination of drugs metabolized in the liver by microsomal oxidation (including diazepam, ibuprofen, indomethacin, clarithromycin, prednisone, propranolol, terfenadine, warfarin, phenytoin).
Lansoprazole reduces clearance of theophylline by 10%. Lansoprazole changes the pH-dependent absorption of drugs belonging to the groups of weak acids and bases. Sucralfate reduces the bioavailability of lansoprazole by 30% Antacids slow down and reduce the absorption of lansoprazole (they should be administered for 1 hour or 1-2 hours after administration of lansoprazole).
You should store Lansoprazole capsules out of reach of children at room temperature.