Nexpro (esomeprazole) is a...
Nexpro (esomeprazole) is a non-prescription (otc) medication that lowers the secretion of gastric glands. Esomeprazole belongs to a group of stomach medications called proton pump inhibitors (H+-K+-ATPase)
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Nexpro (esomeprazole) is a OTC medication that lowers the secretion of gastric glands. Esomeprazole belongs to a group of stomach medications called proton pump inhibitors (H+-K+-ATPase). Esomeprazole magnesium blocks the secretion of hydrochloric acid, inhibits basal and stimulated gastric secretion. It is used to treat gastroesophageal reflux disease, erosive reflux esophagitis, gastric ulcer and duodenal ulcer and other diseases associated with overproduction of stomach acid in the stomach. The medication comes in the form tablets 20mg and esomeprazole 40mg. The medication is made by the pharmaceutical company Torrent under the commercial name Nexpro. Esomeprazole is a name of the active ingredient of a well-known medication Nexium made by Astra Zeneca. Nexpro (esomeprazole) is a generic medication.
Esomeprazole is S-isomer of omeprazole, decreases the secretion of gastric acid by specific inhibition of the proton pump in parietal cells. S-and R-isomers of omeprazole have similar pharmacodynamic activity. Esomeprazole magnesium is a weak base that inhibits in parietal cells the enzyme - proton pump - H +, K +-ATPase. By inhibiting this enzyme Esopemrazole magnesium prevents the production of hydrochloric acid in the stomach by parietal cells. Esomeprazole inhibits both basal and stimulated acid secretion. Effect of esomeprazole develops within 1 hour after oral administration of 20 mg or 40 mg.
Esomeprazole is rapidly absorbed into the gastrointestinal tract after oral administration. C max is achieved in 60-120 minutes. Bioavailability is esomeprazole 40 mg is 64%, increasing up to 90% in case of re-admission. The bioavailability of esomeprazole 20mg is 50%. Esomeprazole binds to plasma proteins by 97%. The medication is metabolized in the liver under the action of CYP 2S19 of cytochrome P450. Esomeprazole is eliminated by kidney with urine. A smaller part of esomeprazole is excreted in the feces.
Esomeprazole magnesium is indicated for use in:
Esomeprazole comes in the form of oral tablets 40mg and 20mg. The correct esomeprazole dosage depends on the condition treated, concomitant diseases, and patient's age. Of Esomeprazole 40 mg tablets should be taken orally, usually once daily.
Do not take esomeprazole magnesium if the following conditions apply to you:
Breastfeeding Which Esomeprazole side effects are possible during the treatment?
Generic Nexium (esomeprazole) is well tolerated and side effects usually observed in patients with hypersensitivity. Possible Esomeprazole side effects include:
Make sure to inform your doctor if you take any of the following medicines:
Esomeprazole tablets should be stored out of reach of children at dry place and at room temperature.