Generic Glucophage contains the same...
Generic Glucophage contains the same active ingredient as brand medication - Metformin. It is used for the treatment of Diabetes type II by controlloing sugar bood levels.
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Active ingredient: Metformin
Generic Glucophage is not a brand drug. Generic drug contains the same active ingredient as brand medication - Metformin- however, excipients, manufacturer, form, shape of tablets, commercial name differ. It is believed that generic drug works the same as brand; however pharmacokinetic characteristics (absorption, distribution, elimination) may differ as well.
Metformin is an oral antidiabetic preparation that is related to a group of biguanides. The mechanism of treatment is a possibility to inhibit gluconeogenesis. Metformin increases the sensibility of peripheral receptors to insulin and stimulates glucose uptake by muscle cells. It is also able to reduce the level of glucose in blood, both basic level and the one after having a meal. Metformin does not stimulate the release of insulin and therefore does not lead to a hypoglycemia; it also does not cause any hypoglycemic action on a healthy person.
Metformin helps to decrease body weight considerably for people suffering from diabetes or obesity. It also reduces your appetite, enforces anaerobic glycolysis and decreases glucose resorption into G.I. Tract, causes hypolipidemic and fibrinolytic actions.
In general generic Glucophage exert the following actions:
The maximum concentration of Metformin is reached in 2.5 hours after taking the medicine. The maximum concentrations of Metformin in blood plasma have not exceeded 4mkg/ml. During medicine administration in the recommended doses, the constant concentrations of plasma in blood are being attained within 24-48 hours and form, as a rule, less than 1 mkg/ml. Meal taking decreases and slows down Metformin resorption.
The absolute oral Metformin bioavailability forms aproximately 50 - 60% for healthy people. Metformin slightly interacts with the proteins in blood.
20 - 30% of the given dose are excreted with urine by kidney in unchanged form by glomerular filtration and tubular secretion. The time of half-excretion is approximately 6.5 hours. In case of kidney dyspraxia, renal clearance decreases proportionally to creatine clearance. In that case the time of half-excretion and plasma concentration in the blood is increased respectively.
Generic Glucophage is a prescription medication meaning that it can be used only after consultation with your doctor. Do not use Metformin on your own initiative without your doctor's approval. Metfotmin tablets are taken during or after meal. Tablets should be swallowed whole washing down with sufficient amount of water. The dose is indicated only by your doctor. Maximal daily dose is 3g/daily. The medication should be taken at the same time each day to maintain the constant level of Metfotmin and glucose in your blood.
Generic Glucophage is contraindicated for use in the following conditions:
The drug must not be taken in the following conditions:
Children's age (efficacy and safety of children has not been determined), elderly (over 65) age (due to slow metabolism is necessary to assess benefit / risk).
Generic Glucophage may cause the following side effects:
This is not complete list of glucophage side effects. If any of these or other side effects occur during the treatment with generic glucophage make sure to consult your doctor.
Generic Glucophage should not be combined with the following medicines:
Store the medication at dry and protected from light place out of reach of children. Do not store the medicine in the bathroom.