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Sale! Generic Evista 60mg (raloxifene) View larger

Generic Evista 60mg (raloxifene)

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Generic Evista is a prescription medication used to prevent and treat osteoporosis in postmenopausal women. Generic Evista is not the brand medication, it contains the same active ingredient as brand name- Raloxifene, however, commercial name, manufacturer, shape and form of tablets, sometimes pharmacokinetic characteristics (absorption, distribution, metabolism, and elimination) may differ.

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Generic Evista.

International name: Raloxifene

Generic Evista is which made by Cipla and comes under the name Ralista. It is believed that generic Evista (Ralista) works the same as brand medicine. Raloxifene belongs to a group of medicines called Selective Estrogen Receptor Modulators. It acts as an agonist on tissues not associated with reproduction, and as an antagonist on reproductive tissue. Generic Evista exerts its therapeutic action via binding with estrogen receptor and regulation gene expression. 

Generic Evista reduces the process of resorption of bone tissue and normalizes the balance of calcium in the body, primarily by reducing the loss of calcium with the urine.

Raloxifene does cause endometrium proliferation, does not increase the size of the uterus.  Bleeding or bleeding in the menopause are not common while the treatment with Raloxifene. There are no described any cases of endometrial cancer de novo. Also hyperplasia of the breast tissue are not associated with Raloxifene uses. Raloxifene helps reduce swelling and tenderness of mammary glands. Along with its anti-tumor effect generic Evista reduces the amount of LDL ("bad cholesterol") in the blood without affecting blood HDL and triglycerides blood levels. Raloxifene also reduces fibrinogen of the blood plasma.

After oral administration Raloxifene is quickly absorbed into the blood circulation from the gastrointestinal tract. It is undergone to intensive metabolism by glucuronidation while the first pass through the liver. There are found3-conjugated metabolites. Absolute bioavailability of raloxifene is 2%.  Raloxifene is widely distributed in the body.  It binds to plasma proteins by 98-99%.  Half life period is 27.7 hours. Raloxifene is eliminated with faeces 95% and 5% with urine within 5 days.

Indication:

Generic Evista is used:

  • to treat and prevent osteoporosis in postmenopausal women
  • to lower the risk of breast cancer

How generic Evista (Ralista) is taken?

The medication is prescribed only by a doctor and treatment with Raloxifene (Ralista) should be carried only under your doctor supervision. In most cases the recommended dose is 60mg once daily. It is important to get enough calcium and Vitamin D while the treatment with Ralista. You need to get not less than 1500mg calcium daily, and 400-800 IU of vitamin D. You can take the medication with or without food. Tablets must be taken whole swallowing with a glass of water. Tablets must not be chewed or crashed. It is preferably to take Ralista tablets at the same time each day.

Contraindications

Raloxifene is contraindicated for use in the following conditions:

  • Individual intolerance or reactions of hypersensitivity to any of the medication ingredients
  • History of blood clots
  • History of heart attacks, strokes or mini strokes
  • Congestive heart failure
  • High triglyceride blood levels
  • Severe liver diseases
  • Severe kidney diseases
  • High blood pressure
  • Cancer
  • Arrhythmia
  • Men
  • Children
  • Pregnancy
  • Breastfeeding

Ralista should be used with caution in the following conditions:

  • Allergies to foods and medicines
  • Smoking
  • Drinking alcohol frequently
  • Undergoing any surgical interventions

Evista is not indicated to prevent heart diseases. Even more it can increase the risk of heart attacks and strokes especially before any surgical procedures. Therefore it is recommended to stop taking Ralista if you are upcoming any surgeries.

The medication may exert negative effects on the uterine mucous lining . Make sure to inform your doctor if you experience any unusually uterine bleedings while the treatment with generic Evista.

Side effects

Evista may cause the following side effects:

Hemopoietic system: thrombocytopenia, thromboembolia (thrombosis of the deep veins), embolia of the pulmonary artery, thrombosis of the retina's veins

Cardiovascular system: vasodilation (hot flashes)

Others: peripheral edema, muscle spasms

The most common and observed in clinical trials side effects include:

  • Sinus infection
  • Other infections
  • Water retention
  • Pain in the joints
  • Insomnia
  • Flu-like symptoms
  • Pneumonia
  • Increased sweating
  • Leg cramps
  • Headache
  • Weight gain
  • Vaginal discharges

In rare cases Ralista may cause sings of blood clots, heart attacks, strokes.

Evista and overdose

Do not exceed the recommended dosage of Evista generic. Seem immediate medical attention if you took too much of generic Evista dosage. Possible Raloxifene overdose symptoms include:

  • Diarrhea
  • Hot flashes
  • Skin rash
  • Muscle spasms including leg cramps
  • Tremor
  • Problems with coordination
  • High alkaline phosphate levels
  • Nausea and vomiting

Drug interaction

Raloxifene should not be used in combination with the following medicines:

  • Cholesterol medication like bile acid sequestrates. Bile acid sequestrates may bind the medication in the intestine and prevent the absorption of Raloxifene into the blood circulation
  • Benzodiazepines (Diazepam)
  • Estrogen medications. Estrogens may make Raloxifene less effective
  • Oral birth control pills may make Raloxifene less effective as well
  • Thyroid preparations. Evista may make thyroid pills less effective
  • Blood thinners. You need to check your prothrombin time while treatment with Warfarin and Evista.

Storage

Store the medication at dry and protected from light place out of reach of children. Do not store the medication in the bathroom.

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