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Generic Avandia

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Avandia is hypoglycemic medication used to treat diabetes type 2 (insulin non-dependent diabetes). The medication can be used as monotherapy in those patients where physical exercises and diet are not effective to achieved desired level of blood glucose.

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Generic Avandia

Avandia is hypoglycemic medication used to treat diabetes type 2 (insulin non-dependent diabetes). The medication can be used as monotherapy in those patients where physical exercises and diet are not effective to achieved desired level of blood glucose. Rosiglitazone can be used in combination with other medicines like Glucophage, Actos or insulin.

Generic Avandia is not a brand medication. It contains the same active ingredients as brand Avandia, however, commercial name, manufacturer, form and shape of tablets, excipients may differ. Also pharmacokinetic characteristics such as absorption, distribution, elimination may differ as well.  Generic Avandia can be used only after consultation with your doctor.

Therapeutic action

Avandia is oral hypoglycemic drug, a thiazolidinediones derivative which belongs to a group of selective antagonists of nuclear receptor PPARG (peroxisomal proliferator activated receptor gamma). Generic Avandia improves the flow of metabolic process by reducing blood glucose, circulating insulin and free fatty acids. Avandia lowers blood glucose levels by increasing insulin sensitivity of adipose tissue, skeletal muscle and liver tissue.

Avandia improves the function of beta-cells, as evidenced by the increase in mass of pancreatic islets of Langerhans (pancreatic islets) and insulin. Rosiglitazone prevents the development of hyperglycemia, significantly slows the development of renal dysfunction in diabetes mellitus and arterial hypertension, does not stimulate the secretion of insulin by the pancreas and does not cause hypoglycemia.

One of the main features of Avandia consists in significant reduction of free fatty acids in the blood.

After oral administration generic Avandia is quickly absorbed into the blood circulation. The absolute bioavailability is 99%. Cmax  in the blood plasma is achieved in 1 hour. Food intake decreases Cmax by 20-28% and prolongs Tmax until 1.75hours.  Nearly 99.8% of indicated dosage binds to plasma proteins. Accumulation of rosiglitazone is not observed. Rosiglitazone is metabolized in the liver, metabolites does not have any significant pharmacological effects. The medication is eliminated with urine and faeces.

Avandia is used to treat non insulin-dependent diabetes mellitus type 2:

  • In Monotherapy with inefficiency of diet and physical activity
  • In combination with derivatives of sulfonylurea and metformin to improve glycemic control (triple combination therapy).

Generic Avandia tablets are taken orally with or without food 1 or 2 times daily. The dosage and treatment regimen are indicated individually by a doctor. The dosage depends on clinical picture, the response of the organism to the indicated dosage, drug's tolerability. The medication should be used only under the doctor's supervision. Do not use the medicine without medical consultation.

Contraindications

  • Individual intolerance (including reactions of hypersensitivity in anamnesis)
  • Insulin dependent diabetes mellitus
  • Severe liver diseases
  • Severe kidney diseases
  • Pregnancy
  • Breastfeeding
  • Patients under 18 years of age
  • Water retention

The medication should be used with caution in heart failure and renal failure. Make sure to consult your doctor if you are premenopausal without regular menstrual periods, or upcoming surgery.

Rosiglitazone may increase the risk of bone fractures in women and macular edema in women.

Generic Avandia may cause weight gain. Talk to your doctor if you experience rapid weight gain while taking this medication. Avandia may increase the amount of liver enzymes. In rare cases this may result in liver damage

Some clinical data show that generic Avandia may increase the risk of heart attacks. Seek immediate medical attention if you experience cardiovascular complications.

Overdose

Seek medical attention if you took more than 12mg of Avandia. The symptoms of overdose may include stomach disturbances, extremely low blood sugar levels.

Side effects

Usually nearly 7.5% of patients are required to end the therapy with Avandia because of side effects. Generic Avandia may cause the following side effects:

  • Metabolism: rarely - peripheral edema, hypercholesterolemia, hypoglycemia.
  • Hemopoietic system: anemia.

Cardiovascular system: heart failure (especially in older patients with a prolonged course of diabetes and receiving Avandia dose 8 mg/day), the symptoms of myocardial ischemia (usually in patients receiving combination therapy, compared with patients receiving monotherapy with insulin), in some cases - Congestive heart failure and pulmonary edema.

  • Digestive system: rarely - increased activity of liver enzymes, symptoms of deficiency of liver function.

The most common generic Avandia side effects include:

  • Infections of the upper respiratory system
  • Broken bones in women
  • Anemia
  • Back pain
  • Edema (water retention)
  • Weight gain
  • Headache
  • Injury
  • Sings of high blood sugar levels
  • Sings of low blood sugar levels
  • Swelling in the legs
  • Liver problems
  • Vision changes
  • Sings of allergic reactions

Drug interaction
Generic Avandia should not be used in combination with the following medicines:

  • HIV medication - Atazanavir.  Atazanavir may increase blood levels of Avandia
  • Certain seizure medications. Seizure drugs my decrease Rosiglitazone blood levels
  • Gemfibrozil (Lopid) increases Rosiglitazone blood levels
  • Insulin. When Avandia is used with Insulin there is an increased risk of heart attacks and strokes
  • Nitrates increase the risk of heart attacks and chest pain when used with generic Avandia
  • Rifampin (Rifadin) or Rifapentine (Priftin) may decrease the levels of Rosiglitazone in the blood
  • Ritonavir may increases blood levels of  Rosiglitazone

Storage
Store the medication at dry and protected place out of reach of children at room temperature. Do not store the medication in the bathroom.

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