Fluconazole is an effective...
Fluconazole is an effective broad-spectrum action antifungal medication indicated for yeast infection and treatment of systemic mycosis. It is recommended to prevent recurrent vaginal candidiasis. Fluconazole can be used to prevent mycotic infection in patients with weak immunity.
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Fluconazole is active against opportunistic mycosis, including caused by Candida spp. (Including generalized candidosis associated with weak immune system), Cryptococcus neoformans (including intracranial infection), Microsporum spp. and Ttichoptyton spp; endemic mycosis caused by Blastomyces dermatitis, Coccidioides immitis, including intracranial infections, and Histoplasma capsulatum.
Fluconazole does not affect the activity of liver enzymes as other antifungals. Being highly selective for fungal cytochrome P450, it does not inhibit these enzymes in human organs. Fluconazole inhibits the cytochrome P450 - dependent oxidative processes in human liver microsomes in a less degree in comparison with other antimycotic agents such as itraconazole, clotrimazole, ketoconazole.
After oral administration Fluconazole is almost completely absorbed from the gastrointestinal tract into the blood circulation. The bioavailability is 90%. Cmax is achieved after 0,5-1,5 h after administration. The equilibrium concentration is achieved after 4-5 day of application. Fluconazole binds to plasma proteins by 11-12%. The concentration of active substances in breast milk, joint fluid, saliva, sputum and peritoneal fluid are similar to those in blood plasma. Fluconazole is excreted by kidney with urine in the form of metabolites (20%) and unchanged form (80%). The pharmacokinetics of fluconazole is significantly dependent on renal function.
Yeast infection (Candidiasis):
Mode of administration
Fluconazole comes in the form of tablets 50mg, 100mg, 150mg and 200mg. Unlike yeast infection products , Fluconazole is not used vaginally. It works through the bloodstream to treat yeast infections. You can take the medication with or without food. Fluconazole tablets should be taken whole swallowing with sufficient amount of water.
Fluconazole is contraindicated for use in the following conditions:
Although a single oral dose of Fluconazole is usually enough for treating vaginal yeast infections, it should be noted that this medicine is more likely to cause adverse effects compared to the standard vaginal treatments, such as yeast infection ointment or creams.
Treatment with fluconazole should be continued until clinical remission. Premature termination of treatment leads to relapses. It is necessary to control blood picture, liver and renal function during the treatment. In case of renal impairment the therapy must be discontinued. Hepatotoxic effects of fluconazole is usually reversible meaning that symptoms disappear after cessation of therapy. In case of skin rash (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema polymorphous) developing treatment with fluconazole should be discontinued as well.
The medication must be used with caution in patients with impaired renal function, children, HIV-positive patients.
Fluconazole is usually well tolerated and side effects are not common. The most common Fluconazole side effects include: nausea, headache, stomach discomfort. The frequency of side effects does not exceed 1%.
Other less common Fluconazole side effects include: allergic reactions, anaphylactic reactions, toxic epidermal necrolysis.
Liver and kidney dysfunction, hyperbilirubinemia, increased activity of ALT, AST, alkaline phosphatase.
Convulsions, alopecia, leukopenia, thrombocytopenia, neutropenia, agranulocytosis, hypercholesterolemia, hypertriglyceridemia, hypokalemia.