Bioparox aerosol for treatment of...
Bioparox aerosol for treatment of infectious and inflammatory diseases of the respiratory tract (rhinitis, nasopharyngitis, pharyngitis, laryngitis, tracheitis, tonsillitis, post-tonsillectomy states, sinusitis).
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Antibacterial drug for local application in ENT practice
Dosage form, composition and packaging
Metered aerosol for inhalation in the form of a yellow solution with a peculiar odor.
Bioparox Pharmacological action
Antibiotic for local application. It has antibacterial and anti-inflammatory activity.
In vitro Bioparox is active against: Streptococcus spp. group A, Streptococcus pneumoniae (the old name - Pneumococcus), Staphylococcus spp., some strains of Neisseria spp., some of the anaerobes, as well as Mycoplasma spp., fungi of the genus Candida. It is assumed that fusafungine has similar activity in vivo.
Fusafungine has a pronounced anti-inflammatory effect by reducing the concentration of tumor necrosis factor (TNF) and the suppression of the synthesis of free radicals by macrophages while maintaining phagocytosis.
Bioparox should be used with caution in patients predisposed to allergic reactions and bronchospasm.
There is limited information on fusafungine overdose.
Symptoms: poor circulation, numbness in the mouth, dizziness, increased soreness of the throat, burning in the throat.
Treatment: in case of overdose, there should be symptomatic treatment followed by supervision.
Specific studies concerning interactions with other drugs have not been conducted.
Pregnancy and lactation
Clinical data on the use of the drug in pregnancy are not available. The drug should be prescribed during pregnancy with caution.
In the absence of data on the excretion in breast milk, the use of the Bioparox drug in breastfeeding women is not recommended.
In long-term studies in laboratory embrio-animals, genotoxic effects and teratogenic effects on the fetus have not been revealed.
Bioparox Side effects
Allergic reactions are very rare. The development of local, rapidly vanishing reactions is possible, mainly in patients susceptible to allergies.
General disorders and symptoms: very often - sneezing, unpleasant taste in the mouth, redness of the conjunctiva; often - dryness of mucous membranes of the respiratory tract, the sensation of throat irritation, coughing, nausea; unknown frequency - vomiting. Discontinuation of treatment is usually not required.
Immune system: very rarely - anaphylactic shock.
Respiratory system: very rarely - asthma attacks, asthma attacks, bronchial asthma attacks, shortness of breath, laryngospasm, angioedema, including laryngeal edema.
Skin: very rarely - rash, itching, urticaria.
In case of allergic reactions the drug should be discontinued and its administration should not be resumed. Due to the risk of anaphylactic shock in case of respiratory, skin or laryngeal symptoms (itching, generalized erythema) it is recommended to give an immediate intramuscular injection of epinephrine (adrenaline) in a dose of 0.01 mg/kg. If necessary, another intramuscular injection should be given in 15-20 minutes.
Storage time and conditions
Special storage conditions are not required. Shelf life - 2 years. Do not use after the expiry date printed on the package.
It is not recommended to exceed the duration of the standard 7-day course of treatment in accordance with the general rules of the use of antibiotics. At the end of the 7-day course of treatment, the patient should see a doctor to evaluate the effectiveness of therapy.
May cause skin irritation.
The drug includes a small amount of ethanol, less than 100 mg per dose.
Do not spray into eyes.
The drug should not be stored in proximity to the strong heat sources.
Do not expose to temperatures exceeding 50°C.
Do not break the airtightness of the container and do not burn it, even after the drug has been used up.
Effects on the ability to drive and use machines
Bioparox does not affect the ability to drive vehicles or speed of psychomotor reactions.
Bioparox Application in children
It is contraindicated for children under 2.5 years of age.