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Baneocin Ointment

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Baneocin is a combined antibacterial drug for topical application. Baneocin ointment contains two antibiotics which have a bactericidal effect, neomycin and bacitracin.

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Baneocin

Dosage form, composition and packaging

Ointment for external use, yellowish, homogeneous, with a faint characteristic odor.

 

1 g

bacitracin (in the form of zinc bacitracin)

250 IU

neomycin (neomycin sulphate form)

5000 IU

Baneocin Ointment Pharmacological action

Combined antibacterial drug for topical application. It contains two antibiotics which have a bactericidal effect, neomycin and bacitracin.

Bacitracin is a polypeptide antibiotic which inhibits bacterial cell wall synthesis. Active against gram-positive (Streptococcus spp./including beta-hemolytic streptococcus, Staphylococcus spp.) and some gram-negative microorganisms. Resistance to bacitracin is rare.

Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. It is active against gram-positive and gram-negative bacteria.

By using a combination of the two antibiotics a wide spectrum of action of the drug and synergistic effect against a number of microorganisms, such as staphylococci, are achieved.

Baneocin Ointment Dosage

Ointment is applied thinly to the affected areas 2-3 times per day. It is possible to apply the ointment under occlusion.

The Baneocin ointment may be used as an additional treatment means in the postoperative period. Application of the ointment on the bandage is preferable during topical treatment of infected wounds and cavities (e.g., bacterial infections of the ear canal without perforation of the tympanic membrane, wounds or surgical incisions healing by secondary intention).

Baneocin Ointment Overdose

Currently, no cases of Baneocin overdose have been reported.

Baneocin Ointment interactions

If there is a systemic absorption, then, in case of simultaneous use of cephalosporins or aminoglycoside antibiotics, the risk of nephrotoxic reactions is increased.

In case of simultaneous application of Baneocin and ethacrynic acid or furosemide the risk of oto-and nephrotoxic reactions is increased.

In case of systemic absorption during the simultaneous use of Baneocin with opioid analgesics, anesthetics and muscle relaxants the risk of neuromuscular blockade is increased.

There were no cases of incompatibility of bacitracin and neomycin.

Baneocin Pregnancy and lactation

Use of Baneocin during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Baneocin Ointment Side effects

Allergic reactions: long-term use - redness, dry skin, skin rash, itching. Allergic reactions mostly occur by the type of contact eczema (50% of cases are linked with polyvalent allergy to other aminoglycosides) and are rare.

Systemic effects: in case of extensive lesions of the skin one should consider the possibility of absorption of the drug and the development of oto-and nephrotoxic effects and disorders of neuromuscular conduction.

When applied topically to the skin, mucous membranes and wound surfaces, the drug is usually well tolerated.

Storage time and conditions

The drug should be stored out of children’s reach at a temperature not exceeding 25°C. Shelf life - 3 years.

Baneocin Ointment Indications

Treatment of infectious-inflammatory skin diseases caused by sensitive microorganisms:

  • focal infections of the skin, including boils, carbuncles (after surgery), staphylococcal sycosis, deep folliculitis, suppurative hidradenitis, paronychia;
  • bacterial  skin infections of limited distribution, including contagious impetigo, infected ulcers of the lower extremities, secondarily infected eczema,  infection in cases of secondary dermatoses, cuts, abrasions, burns, in cosmetic surgery and skin grafts (also for the prevention and to impregnate bandages).

Prevention of infection after surgery (in combination therapy in the postoperative period).

Baneocin Ointment Contraindications

  • extensive skin lesions (risk of ototoxic effects accompanied by hearing loss);
  • pronounced disturbances of renal excretory function (due to heart or kidney failure) with existing diseases of cochleovestibular system (if systemic absorption of the drug is possible);
  • increased sensitivity to bacitracin, neomycin, or to other aminoglycosides.

Cautions

When used in doses which are substantially higher than recommended ones, due to possible absorption one should pay attention to symptoms suggestive of nephro- or ototoxic reactions.

Since the risk of toxic effects increases with a decrease in the liver and/or kidney function, in patients with hepatic and/or renal failure blood and urine tests should be performed, together with audiometric examination prior to and during treatment with Baneocin.

In case of possible absorption (extensive violations of skin integrity) it is necessary to monitor the possible signs of neuromuscular blockade, especially in patients with acidosis, myasthenia gravis, or other neuromuscular disorders. In case of development of neuromuscular blockade calcium supplements or neostigmine should be used.

During long-term use of the drug it is necessary to monitor possible excessive growth of resistant organisms. If necessary, appropriate treatment should be assigned.

In the case of using the drug in children, patients with impaired liver and kidney function, as well as in case of a large area of the surface being treated, long-term use and deep skin lesions one should consult a doctor first.

In case of development of allergic reactions and superinfection the drug should be discontinued.

In case of renal impairment

When used in doses which are substantially higher than recommended ones, due to possible absorption one should pay attention to symptoms suggestive of nephro- or ototoxic reactions.

Since the risk of toxic effects increases with a decrease in kidney function, in patients with hepatic and/or renal failure blood and urine tests should be performed, together with audiometric examination prior to and during treatment with Baneocin.

The drug is contraindicated in cases of severe renal impairment (due to heart or kidney failure).

In case of abnormal liver function

Since the risk of toxic effects increases with a decrease in liver function, in patients with hepatic and/or renal failure blood and urine tests should be performed, together with audiometric examination prior to and during treatment with Baneocin.

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