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Generic Biseptol (Bactrim)

Generic Biseptol is a combined antibacterial medication with possesses a broad spectrum of bactericidal activity. Bactericidal effect of the medication is associated with blocking the biosynthesis of folates in microbial cells.

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  • 400/80mg - 100 tablets
  • 400/80mg - 200 tablets

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Biseptol. Generic Biseptol

Trade name: Biseptol

INN: sulfamethoxazole, trimethoprim

Biseptol pharmacological action

Generic Biseptol is a combined antibacterial medication with possesses a broad spectrum of bactericidal activity. Bactericidal effect of the medication is associated with blocking the biosynthesis of folates in microbial cells. Sulfamethoxazole is a sulfanilamide antibiotic which inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Without tetrahydrofolic acid bacteria are not able to grow, make proteins and multiply. Generic Biseptol is effective against a wide variety of microorganisms including gram-positives and gram-negatives. Generic Biseptol does not act on Treponema pallidum, Mycoplasma, Mycobacterium tuberculosis.

Biseptol Pharmacokinetics:

After administration the medication is completely absorbed from the gastrointestinal tract into the blood circulation. The maximal blood concentration is achieved in 1-4 hours.

Trimethoprim has a good penetration into the cells and tissue of the lungs, kidney, prostate, bile, saliva, sputum, cerebrospinal fluid. Nearly 50% of trimethoprim bind to proteins. Half-life period varies from 8.6 to 17 hours. Trimethoprim is eliminated by kidneys with urine (nearly 50% in unchanged for). Nearly 66% of sulfamethoxazole bind to plasma proteins, and half-life period is 9 to 11 hour. Sulfamethoxazole is mainly eliminated by kidney with urine (15-30% in active form)

Biseptol indications

The drug is used for the treatment of infections caused by susceptible to the co-trimoxazol microorganisms:

  • Respiratory infections (bronchitis, pneumonia, lung abscess, pleural empyema, otitis media, sinusitis)
  • Meningitis
  • Brain abscess
  • Urinary tract infections (pyelonephritis, urethritis, salpingitis, prostatitis), including gonorrhea
  • Gastrointestinal tract infections (dysentery, cholera, typhoid, paratyphoid, diarrhea)
  • Skin and soft tissue infections (pyoderma, furunculosis)


Generic Biseptol should not be taken in the following conditions:

  • Hypersensitivity to trimethoprim and / or sulfamethoxazole or sulfonamides
  • Pregnancy
  • Breastfeeding
  • Children
  • Infants
  • Severe cardiovascular diseases
  • Liver diseases
  • Kidney and hematologic diseases
  • Deficiency of glucose-6-phosphate dehydrogenase

Bisptol should be used with caution in patients with anemia associated with deficiency of folic acid in the organism, bronchial asthma, a history of allergic reactions

Generic Biseptol dosage and administration

The medication is used orally swallowing whole with sufficient amount of fluids. The dose of the drug should be specified by a health provider. It is not recommended to take the drug without medical consultation. The duration of treatment varies from 5 to 14 hours. In prolonged treatment (longer than 5 days) you should regularly control you blood picture.

Biseptol drug interaction

The drug is not recommended to take in conjunction with thiazide diuretics because of the risk of thrombocytopenia (bleeding). Co-trimoxazole increases the anticoagulant activity of warfarin and the anticonvulsant action of phenytoin. Trimethoprim potentiates the action of antidiabetic drugs such as sulfonylureas derivatives. Rifampicin reduces the half-life of trimethoprim. Concomitant application of co-trimoxazole and cyclosporin after surgeries s on the kidneys worsens the condition of patients.

It is not recommended the simultaneous use of the drug with salicylates, butadione, naproxene and para-aminobenzoic acid derivatives.

Generic Biseptol side effects

The drug is generally well tolerated. The most common Biseptol side effects include: headache, depression, dizziness.

In rare cases Biseptol may cause: nausea, vomiting, and other dysfunctions of the gastrointestinal tract including diarrhea, pseudomembranous colitis cholestatic hepatitis), skin rashes (including polymorphonuclear Bullous erythema, Stevens-Johnson, toxic epidermal necrolysis Lyell),

Kidney dysfunction (hematuria, nephritis)

Hematopoietic systems (leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia).

Biseptol overdose systems: Generic Biseptol may cause nausea, vomiting, fainting.


Biseptol Storage

Store in a dry, protected from light

Keep out of reach of children, in a dry and protected from light place

Generic Biseptol - Frequently asked questions

Is generic Biseptol is the same as brand Biseptol or brand Bactrim?

Generic Biseptol contains the same active ingredients as brand Biseptol and Bactrim. The names of generic Biseptol active ingredients are sulfamethoxazole, trimethoprim. The forms of pills, color and amount of excipients may differ.

How can I buy generic Biseptol?

You can buy generic Biseptol using your Visa Card.

Where generic Biseptol is manufactured?

Generic Biseptol which we provide is made in India by well known manufacturer Piramal Healtch Care.

Is generic Biseptol made by Piramal Healtch Care is good as brand preparation?

Yes. The bacteridical activity of generic Biseptol is the same as in brand Biseptol

Where from generic Biseptol will be shipped?

Generic Biseptol which is made by Piramal Healtch Care will be shipped from India

Do I require a prescription to buy Biseptol online?

If you have a valid prescription you can send it to us. If you do not have a prescription it is better to contact your health care provider prior taking Biseptol generic. You should not take the drug on your own initiative without medical approval.

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