Broad-spectrum antibiotic, it is a semisynthetic derivative of rifamycin SV. It irreversibly binds beta-subunits of bacterial enzyme, DNA-dependent RNA polymerase and thus inhibits the synthesis of RNA and proteins of bacteria. As a result of irreversible binding to the enzyme, rifaximin exhibits bactericidal properties against susceptible bacteria.
It has a wide spectrum of antibacterial activity, including most gram-negative and gram-positive, aerobic and anaerobic bacteria that cause gastrointestinal infections, including travelers' diarrhea.
Treatment of gastrointestinal infections caused by bacteria sensitive to rifaximin, including acute gastrointestinal infections; traveler's diarrhea; syndrome of excessive growth of microorganisms in the intestines; hepatic encephalopathy; symptomatic uncomplicated diverticulosis of the colon; chronic inflammation of the intestine.
Prevention of infectious complications during colorectal surgery.
Increased sensitivity to rifaximin and other antibiotics of the rifamycin group.
In case of long-term treatment with high doses of rifaximin or damage to the intestinal mucosa, small amounts of the active agents may be absorbed into the systemic circulation and cause reddish urine color due to the reddish-orange color of antibiotics of rifamycin group.
Rifaximin Application in children
It is used in children older than 12 years of age according to the dosing regimen.
Rifaximin Side effects
The drug is poorly absorbed from the gastrointestinal tract, which eliminates the risk of systemic adverse effects.
Digestive system: in some cases - nausea, dyspepsia, vomiting, abdominal pain/cramps, which usually pass on their own without having to change the dose or stop the therapy.
Allergic reactions: rarely - urticaria.
Adults and children over 12 years of age: 200 mg every 8 hours or 400 mg every 8-12 hours. If necessary, the dose and frequency of administration may be modified under the supervision of a physician. The duration of treatment should not exceed 7 days and is determined by the clinical state of patients. A second course of treatment should be carried out not earlier than in 20-40 days.
Rifaximin Pregnancy and lactation
The usage of the drug during pregnancy is possible only in case of emergency, with caution and under the direct supervision of a physician.
Use of the drug during the breastfeeding period is allowed under medical supervision.